1941. The first immunohistochemical stain was thought up by Albert Coons

Immunostaining is a term to apply any use of an antibody-based method to identify a protein in a tissue.
The first immunohistochemical stain was thought up by Albert Coons in 1941; he used the antigene-antibody interaction and the results were visualized by maker such as fluorescent dye, colloidal gold or radioactive element for example.

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