1956. Rita Levi Montalcini and Stanley Cohen started studies about the Nerve growth factor

In 1986 Rita Levi-Montalcini and Stanley Cohen won the Nobel Prize in Medicine for their discovery of Nerve Growth Factor and Epidermal Growth Factor, respectively.

Nerve growth factor is a small protein which is fundamental for growth, maintenance and survival of neurons: if there is a loss of it, sensitive neurons undergo apoptosis. In fact, binding its receptor, it starts pathways, like MAPK, that facilitate transcriptional regulation of genes promoting cellular living. NGF may be very useful for the treatment of multiple sclerosis; in fact, it promotes myelin repair. Deregulation of this protein has been also associated to Alzheimer’s disease.

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