The original inventor of optical microscope isn’t easy to identify; probably the microscope appeared in the Netherlands in XVI century.
Galileo Galilei during XVII century developed a compound microscope with a convex and a concave lens.
Anton van Leeuwenhoek used his knowledge in grinding lenses to achieve a greater magnification. Thanks to this advancement, he could observe bacteria. He is considered the first microbiologist.
Marcello Malpighi began the analysis of biological structures through the microscope: because of this work, many microscopic anatomical structures are named after Malpighi, including a skin layer (Malpighi layer) and two different Malpighian corpuscles in the kidneys and the spleen, as well as the Malpighian tubules in the excretory system of insects.